翻訳と辞書 Words near each other ・ Phosphoenolpyruvate carboxykinase ・ Phosphoenolpyruvate carboxykinase (ATP) ・ Phosphoenolpyruvate carboxykinase (diphosphate) ・ Phosphoenolpyruvate carboxylase ・ Phosphoenolpyruvate mutase ・ Phosphoenolpyruvate phosphatase ・ Phosphoenolpyruvate—glycerone phosphotransferase ・ Phosphoenolpyruvate—protein phosphotransferase ・ Phosphoenolpyruvic acid ・ Phosphoenolpyruvic carboxykinase ・ Phosphoenolpyruvic carboxylase ・ Phosphoethanolamine N-methyltransferase ・ Phosphoethanolamine/phosphocholine phosphatase ・ Phosphofructokinase ・ Phosphofructokinase 1 ・ Phosphofructokinase 2 ・ Phosphofructokinase deficiency ・ Phosphoglucan, water dikinase ・ Phosphoglucokinase ・ Phosphoglucomutase ・ Phosphoglucomutase (glucose-cofactor) ・ Phosphoglucomutase 3 ・ Phosphogluconate 2-dehydrogenase ・ Phosphogluconate dehydratase ・ Phosphogluconate dehydrogenase ・ Phosphogluconate dehydrogenase (decarboxylating) ・ Phosphoglucosamine mutase ・ Phosphoglycerate ・ Phosphoglycerate dehydrogenase ・ Phosphoglycerate kinase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Phosphofructokinase 2 ： ウィキペディア英語版 Phosphofructokinase 2 Phosphofructokinase 2 (PFK2) or fructose bisphosphatase 2 (FBPase2), is an enzyme responsible for regulating the rates of glycolysis and gluconeogenesis in the human body. It is a homodimer of 55 kDa subunits arranged in a head-to-head fashion, with each polypeptide chain consisting of independent kinase and phosphatase domain. When Ser-32 of the bifunctional protein is phosphorylated, the negative charge causes the conformation change of the enzyme to favor the FBPase2 activity; otherwise, PFK2 activity is favored. The PFK2 domain is closely related to the superfamily of mononucleotide binding proteins including adenylate cyclase, whereas that of FBPase2 is related to a family of proteins that include phosphoglycerate mutases. ==Structure== The monomers of the bifunctional protein are clearly divided into two functional domains. The kinase domain is located on the N-terminal. It consists of a central six-stranded β sheet, with five parallel strands and an antiparallel edge strand, surrounded by seven α helices. The domain contains nucleotide-binding fold (nbf) at the C-terminal end of the first β-strand, and thus resembles the structure of adenylate kinase. On the other hand, the phosphatase domain is located on the C-terminal. It resembles the family of proteins that include phosphoglycerate mutases (PGMs) and acid phosphatases. The domain has a mixed α/ β structure, with a six-stranded central β sheet, plus an additional α-helical subdomain that covers the presumed active site of the molecule.〔 Finally, N-terminal region modulates PFK2 and FBPase2 activities, and stabilizes the dimer form of the enzyme.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Phosphofructokinase 2」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.